Coronavirus Origins
I’m going to regret writing about this, but it’s not a topic to be ignored. Where did the current coronavirus come from? If you ask that question, you get all sorts of answers from all sorts of people....
View ArticleWaiving IP
The announcement by the Biden administration about waiving IP rights to the coronavirus vaccines obviously calls for some comment. Keep in mind that I have been doing research in the pharma industry...
View ArticleRussian Vaccine Behavior
In the last post, I mentioned the Twitter response to the Brazilian rejection of the Gamaleya vaccine. I believe that the official blue-check-marked “Sputnik V” Twitter account is run by the Russian...
View ArticleBlood Clots and the AZ Vaccine, Revisited
Once again, what’s going on with vascular events and the AZ/Oxford vaccine? I last wrote about this situation a couple of weeks ago, and it’s taken some real turns since then. At that point several EU...
View ArticleThe President’s Coronavirus Treatment
I’ve had emails asking me what I think about President Trump’s illness and the course of treatment that he’s under. To be honest, this wasn’t a subject that I really felt like writing about – every...
View ArticleA Brief Note on Immigration and American Science
There’s an article out today from John Maraganore (CEO of Alnylam, immediate past chair of the BIO industry group) and his successor at BIO, Jeremy Levin (CEO of Ovid Therapeutics). They’re making the...
View ArticleAfrica, African-Americans, and the Coronavirus Vaccines
I mentioned yesterday in my post about anti-vaccine arguments that there seemed to be suspicions on social media platforms about vaccine testing in Africa. I’ve been looking around for more of that,...
View ArticleNot Winning Friends, Not Influencing People
Many chemists will by now be aware of the brief, but very loud, incident with Angewandte Chemie and a paper by Tomas Hudlicky that appeared there. Well, it didn’t appear for long – within hours, the...
View ArticleSurgisphere and Their Data
So we have a very strange situation with some recent publications, one that deserves a closer look. The ones I refer to are the recent Lancet retrospective study on hydroxychloroquine use (blogged...
View ArticleSome Commentary
It feels strange to be writing about biomedicine, even about a terrible pandemic, under the current circumstances. I was six years old in 1968 and was thus largely spared that year’s events, so 2020 is...
View ArticleTaking Hydroxychloroquine (May 19 Update)
I was not planning to revisit this topic just yet, but President Trump has forced the issue with his mention yesterday that he’s taking hydroxychloroquine. Let’s try to keep this short: does any...
View ArticleMore Chinese Traditional Medicine, Unfortunately
I mentioned the other day that what was reported as a hydroxychloroquine trial in China may well have been (or at least begun as) a trial of “traditional Chinese medicine” (TCM). It doesn’t take much...
View ArticleAbout Remdesivir and About “Game-Changers”
We’ve had several releases of remdesivir data, and this was not exactly one of those controlled-release formulations. No, this was more in the “chaotic mess” category, with news items coming from...
View ArticleMonoclonal Antibodies for the Coronavirus
Antibodies as a therapy Let’s have a look at what is (in my opinion) probably our best shot at a reasonably short-term targeted therapy against the COVID-19 epidemic: the possibility of using...
View ArticleAnti IL-6 For Coronavirus Patients: Does It Work, or Not?
It’s been looking for some time as if these coronavirus infections need a biphasic approach to therapy – an antiviral approach earlier on, and for those in serious trouble, perhaps a shift to immune...
View ArticleA Close Look at the Frontrunning Coronavirus Vaccines As of April 23
There’s plenty of news on the coronavirus vaccine front, so let’s have a look. If you need some details on the different sorts of vaccines in general, here’s the background post, which should help this...
View ArticleThe Politics of Hydroxychloroquine
I had not been planning to return to the topic of hydroxychloroquine so soon, but here we are. This will not be a calm, measured blog post – fair warning. Yesterday, Dr. Rick Bright was pushed out of...
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Watching For Mutations in the Coronavirus
The coronavirus outbreak has been accompanied by a huge amount of sequencing data, as well it should be. Nextstrain.org is a great place to see this in action: region by region, the spread of the...
View ArticleWhat’s Happening With Remdesivir?
Well, everyone was just dealing with the news that Gilead’s antiviral remdesivir had had two trials suspended in China, when Stat‘s Adam Feuerstein and Matthew Herper broke news last night about a...
View ArticleCoronavirus Vaccine Prospects
Time for another look at the coronavirus vaccine front, since we have several recent news items. Word has come from GSK and Sanofi that they are going to collaborate on vaccine development, which...
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